| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase 2 |
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| Ligand | BDBM50227631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_597598 (CHEMBL1050561) |
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| IC50 | >30000±n/a nM |
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| Citation |  Giroux, A; Boulet, L; Brideau, C; Chau, A; Claveau, D; Côté, B; Ethier, D; Frenette, R; Gagnon, M; Guay, J; Guiral, S; Mancini, J; Martins, E; Massé, F; Méthot, N; Riendeau, D; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett19:5837-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase 2 |
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| Name: | Prostaglandin E synthase 2 |
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| Synonyms: | C9orf15 | PGES2 | PGES2_HUMAN | PTGES2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41955.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H7Z7 |
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| Residue: | 377 |
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| Sequence: | MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLG
AAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFL
DFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQ
PLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADD
WLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQ
DNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQ
PWYLRVERAITEASPAH
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| BDBM50227631 |
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| n/a |
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| Name | BDBM50227631 |
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| Synonyms: | 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H11ClN4 |
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| Mol. Mass. | 378.813 |
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| SMILES | Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N |
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| Structure | 
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