| Reaction Details |
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 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
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| Ligand | BDBM50305580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_604514 (CHEMBL1074684) |
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| IC50 | 70±n/a nM |
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| Citation |  Kitas, E; Mohr, P; Kuhn, B; Hebeisen, P; Wessel, HP; Haap, W; Ruf, A; Benz, J; Joseph, C; Huber, W; Sanchez, RA; Paehler, A; Benardeau, A; Gubler, M; Schott, B; Tozzo, E Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett20:594-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fructose-1,6-bisphosphatase 1 |
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| Name: | Fructose-1,6-bisphosphatase 1 |
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| Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
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| Type: | Protein |
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| Mol. Mass.: | 36843.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Liver FBPase (P09467) |
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| Residue: | 338 |
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| Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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| BDBM50305580 |
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| n/a |
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| Name | BDBM50305580 |
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| Synonyms: | 5-(2-hydroxyethyl)-4-methyl-N-(4-methyl-5-(methylthio)thiazol-2-ylcarbamoyl)thiophene-2-sulfonamide | CHEMBL605615 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17N3O4S4 |
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| Mol. Mass. | 407.552 |
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| SMILES | CSc1sc(NC(=O)NS(=O)(=O)c2cc(C)c(CCO)s2)nc1C |
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| Structure | 
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