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TargetFructose-1,6-bisphosphatase 1
LigandBDBM50305581
Substrate/Competitorn/a
Meas. Tech.ChEMBL_604514 (CHEMBL1074684)
IC50 80±n/a nM
Citation Kitas, EMohr, PKuhn, BHebeisen, PWessel, HPHaap, WRuf, ABenz, JJoseph, CHuber, WSanchez, RAPaehler, ABenardeau, AGubler, MSchott, BTozzo, E Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett20:594-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphatase 1
Name:Fructose-1,6-bisphosphatase 1
Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:Protein
Mol. Mass.:36843.58
Organism:Homo sapiens (Human)
Description:Liver FBPase (P09467)
Residue:338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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  Blast E-value cutoff:
BDBM50305581
n/a
NameBDBM50305581
Synonyms:CHEMBL590363 | N-(4-ethyl-5-(methylthio)thiazol-2-ylcarbamoyl)-5-(2-hydroxyethyl)-4-methylthiophene-2-sulfonamide
TypeSmall organic molecule
Emp. Form.C14H19N3O4S4
Mol. Mass.421.578
SMILESCCc1nc(NC(=O)NS(=O)(=O)c2cc(C)c(CCO)s2)sc1SC
Structure
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