Reaction Details |
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Target | Fructose-1,6-bisphosphatase 1 |
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Ligand | BDBM50305569 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_604514 (CHEMBL1074684) |
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IC50 | 70±n/a nM |
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Citation | Kitas, E; Mohr, P; Kuhn, B; Hebeisen, P; Wessel, HP; Haap, W; Ruf, A; Benz, J; Joseph, C; Huber, W; Sanchez, RA; Paehler, A; Benardeau, A; Gubler, M; Schott, B; Tozzo, E Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett20:594-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Fructose-1,6-bisphosphatase 1 |
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Name: | Fructose-1,6-bisphosphatase 1 |
Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
Type: | Protein |
Mol. Mass.: | 36843.58 |
Organism: | Homo sapiens (Human) |
Description: | Liver FBPase (P09467) |
Residue: | 338 |
Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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BDBM50305569 |
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n/a |
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Name | BDBM50305569 |
Synonyms: | CHEMBL590597 | N-(5-bromothiazol-2-ylcarbamoyl)-5-(4-methoxy-2-methylphenyl)-4-methylthiophene-2-sulfonamide |
Type | Small organic molecule |
Emp. Form. | C17H16BrN3O4S3 |
Mol. Mass. | 502.426 |
SMILES | COc1ccc(-c2sc(cc2C)S(=O)(=O)NC(=O)Nc2ncc(Br)s2)c(C)c1 |
Structure |
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