| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50319672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634707 (CHEMBL1118792) |
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| EC50 | 490±n/a nM |
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| Citation |  Ghiron, C; Haydar, SN; Aschmies, S; Bothmann, H; Castaldo, C; Cocconcelli, G; Comery, TA; Di, L; Dunlop, J; Lock, T; Kramer, A; Kowal, D; Jow, F; Grauer, S; Harrison, B; La Rosa, S; Maccari, L; Marquis, KL; Micco, I; Nencini, A; Quinn, J; Robichaud, AJ; Roncarati, R; Scali, C; Terstappen, GC; Turlizzi, E; Valacchi, M; Varrone, M; Zanaletti, R; Zanelli, U Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914). J Med Chem53:4379-89 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50319672 |
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| n/a |
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| Name | BDBM50319672 |
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| Synonyms: | 1-(4-(Morpholin-4-yl)butyl)-3-(4-pyridin-3-ylphenyl)urea | CHEMBL1086331 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N4O2 |
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| Mol. Mass. | 354.446 |
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| SMILES | O=C(NCCCCN1CCOCC1)Nc1ccc(cc1)-c1cccnc1 |
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| Structure | 
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