Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM50323351 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_643964 (CHEMBL1211863) |
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IC50 | 9.4±n/a nM |
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Citation | Adams, CM; Hu, CW; Jeng, AY; Karki, R; Ksander, G; Lasala, D; Leung-Chu, J; Liang, G; Liu, Q; Meredith, E; Rao, C; Rigel, DF; Shi, J; Smith, S; Springer, C; Zhang, C The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase. Bioorg Med Chem Lett20:4324-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
Type: | Protein |
Mol. Mass.: | 57582.15 |
Organism: | Homo sapiens (Human) |
Description: | P19099 |
Residue: | 503 |
Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM50323351 |
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n/a |
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Name | BDBM50323351 |
Synonyms: | 6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isobutyl-6,7-dihydro-5-thia-2,3a,6-triaza-indene 5,5-dioxide | CHEMBL1209625 |
Type | Small organic molecule |
Emp. Form. | C17H22ClN3O2S |
Mol. Mass. | 367.893 |
SMILES | CC(C)CC1n2cncc2CN([C@@H](C)c2ccc(Cl)cc2)S1(=O)=O |r| |
Structure |
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