| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM18792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_666431 (CHEMBL1260235) |
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| Ki | 55.6±n/a nM |
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| Citation |  Nzila, A; Rottmann, M; Chitnumsub, P; Kiara, SM; Kamchonwongpaisan, S; Maneeruttanarungroj, C; Taweechai, S; Yeung, BK; Goh, A; Lakshminarayana, SB; Zou, B; Wong, J; Ma, NL; Weaver, M; Keller, TH; Dartois, V; Wittlin, S; Brun, R; Yuthavong, Y; Diagana, TT Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrob Agents Chemother54:2603-10 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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|
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| BDBM18792 |
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| n/a |
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| Name | BDBM18792 |
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| Synonyms: | 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine | CHEMBL747 | Chlorazin | Cycloguanil |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14ClN5 |
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| Mol. Mass. | 251.715 |
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| SMILES | CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1 |t:3,6| |
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| Structure | 
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