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TargetDihydrofolate reductase
LigandBDBM18792
Substrate/Competitorn/a
Meas. Tech.ChEMBL_666431
Ki 55.6±n/a nM
Citation Nzila ARottmann MChitnumsub PKiara SMKamchonwongpaisan SManeeruttanarungroj CTaweechai SYeung BKGoh ALakshminarayana SBZou BWong JMa NLWeaver MKeller THDartois VWittlin SBrun RYuthavong YDiagana TT Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate. Antimicrob Agents Chemother 54:2603-10 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM18792
n/a
NameBDBM18792
Synonyms:1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine | CHEMBL747 | Chlorazin | Cycloguanil
TypeSmall organic molecule
Emp. Form.C11H14ClN5
Mol. Mass.251.715
SMILESCC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1 |t:3,6|
Structure
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