Reaction Details |
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Target | Protein kinase C beta type |
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Ligand | BDBM50327912 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_665063 (CHEMBL1260173) |
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IC50 | 1212±n/a nM |
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Citation | Bindi, S; Fancelli, D; Alli, C; Berta, D; Bertrand, JA; Cameron, AD; Cappella, P; Carpinelli, P; Cervi, G; Croci, V; D'Anello, M; Forte, B; Giorgini, ML; Marsiglio, A; Moll, J; Pesenti, E; Pittalà, V; Pulici, M; Riccardi-Sirtori, F; Roletto, F; Soncini, C; Storici, P; Varasi, M; Volpi, D; Zugnoni, P; Vianello, P Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity. Bioorg Med Chem18:7113-20 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C beta type |
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Name: | Protein kinase C beta type |
Synonyms: | KPCB_HUMAN | PKC alpha and beta-2 | PKC beta | PKC beta isoform 2 | PKCB | PRKCB | PRKCB1 | Protein Kinase C, beta II | Protein kinase C beta type | Protein kinase C beta type II (PRKCB2) |
Type: | Enzyme |
Mol. Mass.: | 76873.67 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
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Residue: | 671 |
Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
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BDBM50327912 |
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n/a |
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Name | BDBM50327912 |
Synonyms: | 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[3,2-c]pyrazole-5-carboxylic acid((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-amide | CHEMBL1258913 |
Type | Small organic molecule |
Emp. Form. | C29H32N6O3S |
Mol. Mass. | 544.668 |
SMILES | O=C(N[C@H](CN1CCCC1)c1ccccc1)c1cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCOCC3)c2s1 |r| |
Structure |
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