| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50328878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_673957 (CHEMBL1275134) |
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| IC50 | 4±n/a nM |
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| Citation |  Rankovic, Z; Cai, J; Kerr, J; Fradera, X; Robinson, J; Mistry, A; Finlay, W; McGarry, G; Andrews, F; Caulfield, W; Cumming, I; Dempster, M; Waller, J; Arbuckle, W; Anderson, M; Martin, I; Mitchell, A; Long, C; Baugh, M; Westwood, P; Kinghorn, E; Jones, P; Uitdehaag, JC; van Zeeland, M; Potin, D; Saniere, L; Fouquet, A; Chevallier, F; Deronzier, H; Dorleans, C; Nicolai, E Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG. Bioorg Med Chem Lett20:6237-41 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50328878 |
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| n/a |
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| Name | BDBM50328878 |
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| Synonyms: | 3-(2-cyano-6-propylpyrimidin-4-yl)-N-(2-(dimethylamino)ethyl)-N-methyl-5-(trifluoromethyl)benzamide | CHEMBL1271070 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24F3N5O |
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| Mol. Mass. | 419.4434 |
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| SMILES | CCCc1cc(nc(n1)C#N)-c1cc(cc(c1)C(F)(F)F)C(=O)N(C)CCN(C)C |
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| Structure | 
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