Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50328881 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_673957 (CHEMBL1275134) |
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IC50 | 8±n/a nM |
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Citation | Rankovic, Z; Cai, J; Kerr, J; Fradera, X; Robinson, J; Mistry, A; Finlay, W; McGarry, G; Andrews, F; Caulfield, W; Cumming, I; Dempster, M; Waller, J; Arbuckle, W; Anderson, M; Martin, I; Mitchell, A; Long, C; Baugh, M; Westwood, P; Kinghorn, E; Jones, P; Uitdehaag, JC; van Zeeland, M; Potin, D; Saniere, L; Fouquet, A; Chevallier, F; Deronzier, H; Dorleans, C; Nicolai, E Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG. Bioorg Med Chem Lett20:6237-41 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50328881 |
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n/a |
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Name | BDBM50328881 |
Synonyms: | 4-(3-hydroxypropyl)-6-(3-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile | CHEMBL1271273 |
Type | Small organic molecule |
Emp. Form. | C15H12F3N3O |
Mol. Mass. | 307.2705 |
SMILES | OCCCc1cc(nc(n1)C#N)-c1cccc(c1)C(F)(F)F |
Structure |
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