Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50331343 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687130 (CHEMBL1291707) |
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IC50 | 1.2±n/a nM |
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Citation | Yan, X; Wang, Z; Sudom, A; Cardozo, M; DeGraffenreid, M; Di, Y; Fan, P; He, X; Jaen, JC; Labelle, M; Liu, J; Ma, J; McMinn, D; Miao, S; Sun, D; Tang, L; Tu, H; Ursu, S; Walker, N; Ye, Q; Powers, JP The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors. Bioorg Med Chem Lett20:7071-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50331343 |
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n/a |
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Name | BDBM50331343 |
Synonyms: | CHEMBL1290164 | rac-2-(4-(2-cyclopropylphenylsulfonyl)phenyl)-1,1,1-trifluoropropan-2-ol |
Type | Small organic molecule |
Emp. Form. | C18H17F3O3S |
Mol. Mass. | 370.386 |
SMILES | CC(O)(c1ccc(cc1)S(=O)(=O)c1ccccc1C1CC1)C(F)(F)F |
Structure |
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