Reaction Details |
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Target | Carboxylic ester hydrolase |
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Ligand | BDBM50333763 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_700711 (CHEMBL1645750) |
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IC50 | 2.68±n/a nM |
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Citation | Luo, W; Li, YP; He, Y; Huang, SL; Tan, JH; Ou, TM; Li, D; Gu, LQ; Huang, ZS Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation. Bioorg Med Chem19:763-70 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carboxylic ester hydrolase |
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Name: | Carboxylic ester hydrolase |
Synonyms: | BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor |
Type: | Protein |
Mol. Mass.: | 68842.83 |
Organism: | Equus caballus (Horse) |
Description: | Q9N1N9 |
Residue: | 602 |
Sequence: | MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDC
LYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPR
SQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEI
LLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDV
VGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLER
RVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYT
KLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCS
DF
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BDBM50333763 |
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n/a |
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Name | BDBM50333763 |
Synonyms: | CHEMBL1644292 | N1-(3,4-Dimethoxybenzyl)-N6-(1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine |
Type | Small organic molecule |
Emp. Form. | C28H37N3O2 |
Mol. Mass. | 447.6123 |
SMILES | COc1ccc(CNCCCCCCNc2c3CCCCc3nc3ccccc23)cc1OC |
Structure |
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