Reaction Details | |||
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Target | Insulin-like growth factor 1 receptor | ||
Ligand | BDBM50336320 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_716595 (CHEMBL1670374) | ||
IC50 | 27±n/a nM | ||
Citation | Jin, M; Kleinberg, A; Cooke, A; Gokhale, PC; Foreman, K; Dong, H; Siu, KW; Bittner, MA; Mulvihill, KM; Yao, Y; Landfair, D; O'Connor, M; Mak, G; Pachter, JA; Wild, R; Rosenfeld-Franklin, M; Ji, Q; Mulvihill, MJ Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy. Bioorg Med Chem Lett21:1176-80 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin-like growth factor 1 receptor | |||
Name: | Insulin-like growth factor 1 receptor | ||
Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
Type: | Protein | ||
Mol. Mass.: | 154776.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08069 | ||
Residue: | 1367 | ||
Sequence: |
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BDBM50336320 | |||
n/a | |||
Name | BDBM50336320 | ||
Synonyms: | CHEMBL1667938 | trans-4-(8-amino-1-(8-fluoro-2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-N,N-dimethylcyclohexanecarboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C30H29FN6O | ||
Mol. Mass. | 508.5893 | ||
SMILES | CN(C)C(=O)[C@H]1CC[C@@H](CC1)c1nc(-c2ccc3ccc(nc3c2F)-c2ccccc2)c2c(N)nccn12 |r,wU:8.11,wD:5.4,(-1.35,-36.9,;-2.14,-38.22,;-1.38,-39.56,;-3.67,-38.2,;-4.46,-39.53,;-4.16,-36.74,;-3.13,-35.59,;-3.61,-34.12,;-5.11,-33.82,;-6.14,-34.96,;-5.66,-36.42,;-5.6,-32.36,;-4.7,-31.11,;-5.61,-29.86,;-4.84,-28.54,;-5.61,-27.21,;-4.85,-25.88,;-3.3,-25.88,;-2.54,-24.55,;-1.01,-24.55,;-.23,-25.88,;-1,-27.21,;-2.53,-27.21,;-3.3,-28.54,;-2.53,-29.88,;1.3,-25.88,;2.07,-27.22,;3.61,-27.22,;4.38,-25.88,;3.6,-24.54,;2.06,-24.55,;-7.08,-30.35,;-8.41,-29.59,;-8.42,-28.05,;-9.74,-30.36,;-9.74,-31.9,;-8.41,-32.67,;-7.07,-31.89,)| | ||
Structure |