Reaction Details | |||
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Target | Insulin-like growth factor 1 receptor | ||
Ligand | BDBM50336330 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_716595 (CHEMBL1670374) | ||
IC50 | 21±n/a nM | ||
Citation | Jin, M; Kleinberg, A; Cooke, A; Gokhale, PC; Foreman, K; Dong, H; Siu, KW; Bittner, MA; Mulvihill, KM; Yao, Y; Landfair, D; O'Connor, M; Mak, G; Pachter, JA; Wild, R; Rosenfeld-Franklin, M; Ji, Q; Mulvihill, MJ Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy. Bioorg Med Chem Lett21:1176-80 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Insulin-like growth factor 1 receptor | |||
Name: | Insulin-like growth factor 1 receptor | ||
Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
Type: | Protein | ||
Mol. Mass.: | 154776.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08069 | ||
Residue: | 1367 | ||
Sequence: |
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BDBM50336330 | |||
n/a | |||
Name | BDBM50336330 | ||
Synonyms: | CHEMBL1667949 | trans-4-(8-amino-1-(8-fluoro-2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-N-(1H-indol-5-yl)cyclohexanecarboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C36H30FN7O | ||
Mol. Mass. | 595.6681 | ||
SMILES | Nc1nccn2c(nc(-c3ccc4ccc(nc4c3F)-c3ccccc3)c12)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccc2[nH]ccc2c1 |r,wU:27.31,wD:30.38,(5.89,-32.49,;5.89,-34.03,;4.56,-34.8,;4.56,-36.35,;5.89,-37.12,;7.24,-36.34,;8.71,-36.81,;9.61,-35.56,;8.69,-34.31,;9.46,-32.98,;8.69,-31.66,;9.46,-30.32,;11.01,-30.32,;11.77,-28.99,;13.3,-28.99,;14.08,-30.32,;13.31,-31.65,;11.77,-31.65,;11.01,-32.99,;11.78,-34.32,;15.61,-30.32,;16.38,-31.66,;17.92,-31.66,;18.7,-30.32,;17.92,-28.99,;16.38,-28.99,;7.23,-34.8,;9.19,-38.27,;10.7,-38.57,;11.18,-40.04,;10.15,-41.19,;8.64,-40.87,;8.16,-39.42,;10.63,-42.66,;9.85,-43.99,;12.17,-42.68,;12.96,-41.35,;12.2,-40.02,;12.98,-38.69,;14.53,-38.7,;15.56,-37.57,;16.96,-38.21,;16.79,-39.73,;15.29,-40.04,;14.5,-41.38,)| | ||
Structure |