| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50227631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728755 (CHEMBL1686168) |
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| IC50 | >40000±n/a nM |
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| Citation |  Chiasson, JF; Boulet, L; Brideau, C; Chau, A; Claveau, D; Côté, B; Ethier, D; Giroux, A; Guay, J; Guiral, S; Mancini, J; Massé, F; Méthot, N; Riendeau, D; Roy, P; Rubin, J; Xu, D; Yu, H; Ducharme, Y; Friesen, RW Trisubstituted ureas as potent and selective mPGES-1 inhibitors. Bioorg Med Chem Lett21:1488-92 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50227631 |
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| n/a |
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| Name | BDBM50227631 |
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| Synonyms: | 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile | CHEMBL412099 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H11ClN4 |
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| Mol. Mass. | 378.813 |
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| SMILES | Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N |
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| Structure | 
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