| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50348180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_757191 (CHEMBL1803415) |
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| IC50 | 1100±n/a nM |
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| Citation |  Chen, H; Blizzard, TA; Kim, S; Wu, J; Young, K; Park, YW; Ogawa, AM; Raghoobar, S; Painter, RE; Wisniewski, D; Hairston, N; Fitzgerald, P; Sharma, N; Scapin, G; Lu, J; Hermes, J; Hammond, ML Side chain SAR of bicyclicß-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712. Bioorg Med Chem Lett21:4267-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
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| Type: | Enzyme |
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| Mol. Mass.: | 43406.87 |
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| Organism: | Pseudomonas aeruginosa (PAO1) |
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| Description: | P24735 |
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| Residue: | 397 |
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| Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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| BDBM50348180 |
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| n/a |
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| Name | BDBM50348180 |
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| Synonyms: | CHEMBL1800869 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H26N4O6S |
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| Mol. Mass. | 390.455 |
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| SMILES | OCCC[NH+]1CCC[C@@H](CC1)NC(=O)N1CC[C@@H]2[C@H]1C(=O)N2S([O-])(=O)=O |r| |
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| Structure | 
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