Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM50348182 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_757191 (CHEMBL1803415) |
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IC50 | 900±n/a nM |
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Citation | Chen, H; Blizzard, TA; Kim, S; Wu, J; Young, K; Park, YW; Ogawa, AM; Raghoobar, S; Painter, RE; Wisniewski, D; Hairston, N; Fitzgerald, P; Sharma, N; Scapin, G; Lu, J; Hermes, J; Hammond, ML Side chain SAR of bicyclicß-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712. Bioorg Med Chem Lett21:4267-70 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | AMPC_PSEAE | ampC | beta-Lactamase |
Type: | Enzyme |
Mol. Mass.: | 43406.87 |
Organism: | Pseudomonas aeruginosa (PAO1) |
Description: | P24735 |
Residue: | 397 |
Sequence: | MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISL
KGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWP
ALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNP
SIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVG
PGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEA
YDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRD
LGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
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BDBM50348182 |
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n/a |
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Name | BDBM50348182 |
Synonyms: | CHEMBL1800871 |
Type | Small organic molecule |
Emp. Form. | C16H29N5O5S |
Mol. Mass. | 403.497 |
SMILES | CN(C)CC[NH+]1CCC[C@@H](CC1)NC(=O)N1CC[C@@H]2[C@H]1C(=O)N2S([O-])(=O)=O |r| |
Structure |
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