| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
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| Ligand | BDBM50349252 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_759750 (CHEMBL1811699) |
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| IC50 | >1000±n/a nM |
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| Citation |  Xu, B; Feng, Y; Cheng, H; Song, Y; Lv, B; Wu, Y; Wang, C; Li, S; Xu, M; Du, J; Peng, K; Dong, J; Zhang, W; Zhang, T; Zhu, L; Ding, H; Sheng, Z; Welihinda, A; Roberge, JY; Seed, B; Chen, Y C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett21:4465-70 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 2 |
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| Name: | Sodium/glucose cotransporter 2 |
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| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
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| Type: | Protein |
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| Mol. Mass.: | 72902.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31639 |
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| Residue: | 672 |
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| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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| BDBM50349252 |
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| n/a |
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| Name | BDBM50349252 |
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| Synonyms: | CHEMBL1808387 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29ClO7 |
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| Mol. Mass. | 476.947 |
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| SMILES | CC#CCOCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| |
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| Structure | 
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