| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 4 |
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| Ligand | BDBM50353294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_768726 (CHEMBL1831599) |
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| EC50 | 100±n/a nM |
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| Citation |  Hong, SP; Liu, KG; Ma, G; Sabio, M; Uberti, MA; Bacolod, MD; Peterson, J; Zou, ZZ; Robichaud, AJ; Doller, D Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem54:5070-81 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 4 |
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| Name: | Metabotropic glutamate receptor 4 |
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| Synonyms: | GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4 |
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| Type: | Protein |
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| Mol. Mass.: | 101899.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14833 |
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| Residue: | 912 |
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| Sequence: | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI
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| BDBM50353294 |
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| n/a |
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| Name | BDBM50353294 |
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| Synonyms: | CHEMBL1830915 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N6OS |
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| Mol. Mass. | 314.366 |
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| SMILES | COc1ccnc(Nc2nc-3c(CCCc4[nH]ncc-34)s2)n1 |
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| Structure | 
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