| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50353458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_768152 (CHEMBL1833190) |
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| Ki | 4.9±n/a nM |
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| Citation |  Lu, K; Jiang, Y; Chen, B; Eldemenky, EM; Ma, G; Packiarajan, M; Chandrasena, G; White, AD; Jones, KA; Li, B; Hong, SP Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists. Bioorg Med Chem Lett21:5310-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39075.64 |
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| Organism: | RAT |
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| Description: | Melanin Concentrating Hormone 1 GPR24 RAT::P97639 |
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| Residue: | 353 |
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| Sequence: | MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNST
VIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLIT
AMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWL
YARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVA
PASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLG
YANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
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| BDBM50353458 |
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| n/a |
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| Name | BDBM50353458 |
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| Synonyms: | CHEMBL1830052 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22ClN3O |
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| Mol. Mass. | 391.893 |
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| SMILES | CN1CC(C1)N1CCc2cc(ccc12)-n1ccc(cc1=O)-c1ccc(Cl)cc1 |
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| Structure | 
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