| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
|---|
| Ligand | BDBM50356977 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_788049 (CHEMBL1919028) |
|---|
| EC50 | >10000±n/a nM |
|---|
| Citation |  Lebois, EP; Digby, GJ; Sheffler, DJ; Melancon, BJ; Tarr, JC; Cho, HP; Miller, NR; Morrison, R; Bridges, TM; Xiang, Z; Scott Daniels, J; Wood, MR; Conn, PJ; Lindsley, CW Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071. Bioorg Med Chem Lett21:6451-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M4 |
|---|
| Name: | Muscarinic acetylcholine receptor M4 |
|---|
| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52841.70 |
|---|
| Organism: | RAT |
|---|
| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
|
|
|
|---|
| BDBM50356977 |
|---|
| n/a |
|---|
| Name | BDBM50356977 |
|---|
| Synonyms: | CHEMBL1916232 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H27N3O3S |
|---|
| Mol. Mass. | 365.49 |
|---|
| SMILES | CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1cccs1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
