Reaction Details |
| Report a problem with these data |
Target | Cytochrome P450 2D6 |
---|
Ligand | BDBM50358201 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_790071 (CHEMBL1925461) |
---|
IC50 | >30000±n/a nM |
---|
Citation | Kaku, T; Hitaka, T; Ojida, A; Matsunaga, N; Adachi, M; Tanaka, T; Hara, T; Yamaoka, M; Kusaka, M; Okuda, T; Asahi, S; Furuya, S; Tasaka, A Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. Bioorg Med Chem19:6383-99 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 2D6 |
---|
Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
BDBM50358201 |
---|
n/a |
---|
Name | BDBM50358201 |
Synonyms: | CHEMBL1921976 | US9611270, orteronel |
Type | Small organic molecule |
Emp. Form. | C18H17N3O2 |
Mol. Mass. | 307.3465 |
SMILES | CNC(=O)c1ccc2cc(ccc2c1)[C@@]1(O)CCn2cncc12 |r| |
Structure |
|