Reaction Details |
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Target | Glucagon receptor |
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Ligand | BDBM50358364 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_789414 (CHEMBL1924336) |
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IC50 | 41±n/a nM |
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Citation | Sinz, C; Chang, J; Lins, AR; Brady, E; Candelore, M; Dallas-Yang, Q; Ding, V; Jiang, G; Lin, Z; Mock, S; Qureshi, S; Salituro, G; Saperstein, R; Shang, J; Szalkowski, D; Tota, L; Vincent, S; Wright, M; Xu, S; Yang, X; Zhang, B; Tata, J; Kim, R; Parmee, E Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists. Bioorg Med Chem Lett21:7131-6 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucagon receptor |
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Name: | Glucagon receptor |
Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
Type: | Enzyme |
Mol. Mass.: | 54026.92 |
Organism: | Homo sapiens (Human) |
Description: | P47871 |
Residue: | 477 |
Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
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BDBM50358364 |
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n/a |
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Name | BDBM50358364 |
Synonyms: | CHEMBL1922712 |
Type | Small organic molecule |
Emp. Form. | C26H20F6N8O3 |
Mol. Mass. | 606.4792 |
SMILES | COc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12)C(F)(F)F |w:24.26| |
Structure |
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