Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Gastrin/cholecystokinin type B receptor | ||
Ligand | BDBM50007436 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_48263 | ||
IC50 | 3.4±n/a nM | ||
Citation | Horwell, DC; Hughes, J; Hunter, JC; Pritchard, MC; Richardson, RS; Roberts, E; Woodruff, GN Rationally designed"dipeptoid" analogues of CCK. alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties. J Med Chem34:404-14 (1991) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gastrin/cholecystokinin type B receptor | |||
Name: | Gastrin/cholecystokinin type B receptor | ||
Synonyms: | Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 49196.59 | ||
Organism: | MOUSE | ||
Description: | Cholecystokinin A CCKBR MOUSE::P56481 | ||
Residue: | 453 | ||
Sequence: |
| ||
BDBM50007436 | |||
n/a | |||
Name | BDBM50007436 | ||
Synonyms: | CHEMBL334346 | Succinic acid mono-{2-[2-(adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-3-phenyl-propyl} ester | ||
Type | Small organic molecule | ||
Emp. Form. | C36H43N3O7 | ||
Mol. Mass. | 629.7425 | ||
SMILES | C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(O)=O)Cc1ccccc1 |wU:21.28,23.26,17.19,29.33,1.0,wD:1.13,19.20,TLB:15:16:22:19.24.20,THB:18:17:22:19.24.20,18:19:22:16.17.25,20:19:16:21.22.25,(16.6,-9.44,;16.5,-7.94,;16.49,-6.4,;17.58,-5.3,;16.66,-4.07,;17.58,-2.82,;19.04,-3.3,;20.37,-2.51,;21.7,-3.28,;21.7,-4.84,;20.37,-5.61,;19.04,-4.84,;15.18,-8.71,;13.83,-7.96,;13.81,-6.42,;12.49,-8.74,;10.95,-8.71,;10.25,-10.07,;8.77,-10.73,;7.78,-9.59,;6.24,-9.28,;7.89,-8.69,;8.57,-7.36,;9.98,-7.55,;8.48,-8.18,;8.83,-9.73,;17.84,-8.67,;19.16,-7.9,;17.85,-10.21,;19.2,-10.98,;19.2,-12.52,;17.88,-13.29,;17.88,-14.83,;19.23,-15.6,;16.57,-15.62,;15.22,-14.87,;13.9,-15.66,;12.56,-14.9,;13.9,-17.2,;20.51,-10.2,;21.86,-10.95,;23.18,-10.18,;24.51,-10.92,;24.52,-12.48,;23.21,-13.26,;21.86,-12.49,)| | ||
Structure |