| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50001600 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205400 |
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| EC50 | 1030±n/a nM |
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| Citation |  Deal, MJ; Hagan, RM; Ireland, SJ; Jordan, CC; McElroy, AB; Porter, B; Ross, BC; Stephens-Smith, M; Ward, P Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem35:4195-204 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 46261.42 |
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| Organism: | GUINEA PIG |
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| Description: | Neurokinin NK1 TACR1 GUINEA PIG::P30547 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVC
MIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTIST
VVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
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| BDBM50001600 |
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| n/a |
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| Name | BDBM50001600 |
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| Synonyms: | CHEMBL267712 | N-{1-[1-(1-Benzyl-2-{5-[1-(1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butyl]-6-oxo-hexahydro-pyrrolo[3,4-b]pyrrol-1-yl}-2-oxo-ethylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-hydroxy-ethyl}-3-(2,6-diamino-hexanoylamino)-succinamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C48H70N10O11S |
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| Mol. Mass. | 995.195 |
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| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C2C1=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN)C(N)=O |
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| Structure | 
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