Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50065510 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_64042 (CHEMBL873580) |
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IC50 | >10000±n/a nM |
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Citation | Astles, PC; Brealey, C; Brown, TJ; Facchini, V; Handscombe, C; Harris, NV; McCarthy, C; McLay, IM; Porter, B; Roach, AG; Sargent, C; Smith, C; Walsh, RJ Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives. J Med Chem41:2732-44 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49483.43 |
Organism: | RAT |
Description: | ENDOTHELIN B EDNRB RAT::P21451 |
Residue: | 442 |
Sequence: | MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSN
SSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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BDBM50065510 |
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n/a |
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Name | BDBM50065510 |
Synonyms: | 2-(3-Carboxy-1-o-tolyl-propoxy)-4-(thiophen-3-ylmethoxy)-benzoic acid | CHEMBL94279 |
Type | Small organic molecule |
Emp. Form. | C23H22O6S |
Mol. Mass. | 426.482 |
SMILES | Cc1ccccc1C(CCC(O)=O)Oc1cc(OCc2ccsc2)ccc1C(O)=O |
Structure |
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