| Reaction Details |
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 | Report a problem with these data |
| Target | Neuraminidase |
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| Ligand | BDBM4950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_200651 (CHEMBL802983) |
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| IC50 | 67000±n/a nM |
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| Citation |  Taylor, NR; Cleasby, A; Singh, O; Skarzynski, T; Wonacott, AJ; Smith, PW; Sollis, SL; Howes, PD; Cherry, PC; Bethell, R; Colman, P; Varghese, J Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. J Med Chem41:798-807 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuraminidase |
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| Name: | Neuraminidase |
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| Synonyms: | Influenza B Virus Neuraminidase | NA | NRAM_INBLE | Neuraminidase | Neuraminidase B |
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| Type: | Enzyme |
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| Mol. Mass.: | 51446.67 |
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| Organism: | Influenza B virus (B/Lee/40) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MLPSTVQTLTLLLTSGGVLLSLYVSASLSYLLYSDVLLKFSSTKTTAPTMSLECTNASNA
QTVNHSATKEMTFPPPEPEWTYPRLSCQGSTFQKALLISPHRFGEIKGNSAPLIIREPFV
ACGPKECRHFALTHYAAQPGGYYNGTRKDRNKLRHLVSVKLGKIPTVENSIFHMAAWSGS
ACHDGREWTYIGVDGPDNDALVKIKYGEAYTDTYHSYAHNILRTQESACNCIGGDCYLMI
TDGSASGISKCRFLKIREGRIIKEILPTGRVEHTEECTCGFASNKTIECACRDNSYTAKR
PFVKLNVETDTAEIRLMCTKTYLDTPRPDDGSIAGPCESNGDKWLGGIKGGFVHQRMASK
IGRWYSRTMSKTNRMGMELYVKYDGDPWTDSDALTLSGVMVSIEEPGWYSFGFEIKDKKC
DVPCIGIEMVHDGGKDTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
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| BDBM4950 |
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| n/a |
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| Name | BDBM4950 |
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| Synonyms: | (2R,3R,4S)-4-amino-3-acetamido-2-[(2-phenylethyl)carbamoyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | CHEMBL71078 | carboxamide deriv. 4s |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N3O5 |
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| Mol. Mass. | 347.3657 |
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| SMILES | [H][C@]1(OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O)C(=O)NCCc1ccccc1 |r,c:3| |
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| Structure | 
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