| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
|---|
| Ligand | BDBM50369526 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_211304 (CHEMBL820430) |
|---|
| EC50 | >400000±n/a nM |
|---|
| Citation |  Wang, Z; Yang, D; Mohanakrishnan, AK; Fanwick, PE; Nampoothiri, P; Hamel, E; Cushman, M Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability. J Med Chem43:2419-29 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
|---|
| Name: | Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
|---|
| Synonyms: | Tubulin | Tubulin alpha chain /beta chain |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 51441 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Tubulin beta-2B chain |
|---|
| Synonyms: | TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49932.38 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_211651 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
|
|
|
|---|
| Component 2 |
| Name: | Similar to alpha-tubulin isoform 1 |
|---|
| Synonyms: | Tubulin |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 9422.48 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | EBI_18002 |
|---|
| Residue: | 84 |
|---|
| Sequence: | PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQI
VSSITASLRFDGALTVDLTDVQTS
|
|
|
|---|
| BDBM50369526 |
|---|
| n/a |
|---|
| Name | BDBM50369526 |
|---|
| Synonyms: | CHEMBL1627477 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H30O6 |
|---|
| Mol. Mass. | 414.4914 |
|---|
| SMILES | CCOc1cc2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC(=O)c2cc1OC(C)=O)OC(C)=O |
|---|
| Structure | 
|
|---|
Search and Browse
