| Reaction Details |
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 | Report a problem with these data |
| Target | Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
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| Ligand | BDBM50089345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_211317 (CHEMBL818977) |
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| IC50 | 80000±n/a nM |
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| Citation |  Wang, Z; Yang, D; Mohanakrishnan, AK; Fanwick, PE; Nampoothiri, P; Hamel, E; Cushman, M Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability. J Med Chem43:2419-29 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
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| Name: | Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain |
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| Synonyms: | Tubulin | Tubulin alpha chain /beta chain |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 51441 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tubulin beta-2B chain |
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| Synonyms: | TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49932.38 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_211651 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
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| Component 2 |
| Name: | Similar to alpha-tubulin isoform 1 |
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| Synonyms: | Tubulin |
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| Type: | PROTEIN |
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| Mol. Mass.: | 9422.48 |
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| Organism: | Bos taurus |
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| Description: | EBI_18002 |
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| Residue: | 84 |
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| Sequence: | PSPQVSTAVVEPYNSILTTKHLEHSDCFMVDNEAIYDICRRNLDIERPTTRNLNRLMSQI
VSSITASLRFDGALTVDLTDVQTS
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| BDBM50089345 |
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| n/a |
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| Name | BDBM50089345 |
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| Synonyms: | B-Homo-2-ethoxy-3,17beta-estradiol-7-tosylhydrazone | CHEMBL78389 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N2O5S |
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| Mol. Mass. | 512.661 |
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| SMILES | CCOc1cc2C3CC[C@]4(C)[C@@H](O)CCC4C3CC(Cc2cc1O)=NNS(=O)(=O)c1ccc(C)cc1 |w:24.28| |
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| Structure | 
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