| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50116622 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_146228 (CHEMBL754997) |
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| Ki | 4.3±n/a nM |
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| Citation |  Thomas, JB; Atkinson, RN; Namdev, N; Rothman, RB; Gigstad, KM; Fix, SE; Mascarella, SW; Burgess, JP; Vinson, NA; Xu, H; Dersch, CM; Cantrell, BE; Zimmerman, DM; Carroll, FI Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans. J Med Chem45:3524-30 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50116622 |
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| n/a |
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| Name | BDBM50116622 |
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| Synonyms: | CHEMBL117457 | N-[5-(3-Hydroxy-phenyl)-4-methyl-2-phenethyl-2-aza-bicyclo[3.3.1]non-7-yl]-3-piperidin-1-yl-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H43N3O2 |
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| Mol. Mass. | 489.692 |
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| SMILES | CC1CN(CCc2ccccc2)C2C[C@@H](CC1(C2)c1cccc(O)c1)NC(=O)CCN1CCCCC1 |THB:0:1:17:13.14.15,4:3:17:13.14.15| |
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| Structure | 
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