Ki Summary

Reaction Details

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Target

Melanocortin receptor 3

Ligand

BDBM50374672

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_469795 (CHEMBL932305)

EC50

7750±n/a nM

Citation

Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity. J Med Chem51:1026-34 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 3

Name:

Melanocortin receptor 3

Synonyms:

MC3-R | MC3R_MOUSE | Mc3r

Type:

PROTEIN

Mol. Mass.:

35808.24

Organism:

Mus musculus

Description:

ChEMBL_1498848

Residue:

323

Sequence:

MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVI
LAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIF
DSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFI
IYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKG
AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA
FRSLELRNTFKEILCGCNSMNLG

BDBM50374672

n/a

Name

BDBM50374672

Synonyms:

CHEMBL271586

Type

Small organic molecule

Emp. Form.

C46H59N11O7

Mol. Mass.

878.0302

SMILES

NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:29.30,wD:51.53,18.18,40.42,(30.64,-.68,;29.3,.09,;29.31,1.63,;27.97,-.68,;26.64,.1,;26.64,1.64,;27.98,2.4,;27.98,3.94,;25.3,3.95,;23.96,4.72,;23.96,6.26,;22.63,3.95,;21.3,4.72,;19.96,3.95,;19.96,2.41,;18.63,1.64,;17.29,2.41,;18.63,.1,;17.29,-.67,;15.96,.1,;14.63,-.67,;13.3,.11,;11.96,-.66,;11.96,-2.2,;13.31,-2.97,;14.63,-2.2,;17.29,-2.21,;15.96,-2.98,;18.63,-2.98,;18.63,-4.52,;17.29,-5.29,;17.29,-6.83,;15.95,-7.59,;15.95,-9.13,;17.29,-9.9,;18.63,-9.12,;18.62,-7.59,;19.96,-5.29,;19.96,-6.83,;21.3,-4.52,;22.63,-5.29,;22.63,-6.83,;23.96,-7.6,;23.96,-9.14,;25.3,-9.91,;25.3,-11.45,;26.63,-12.22,;23.96,-12.22,;23.96,-4.52,;25.3,-5.29,;23.96,-2.98,;25.3,-2.21,;26.63,-2.98,;28.17,-2.98,;29.08,-1.72,;30.54,-2.19,;30.53,-3.74,;31.67,-4.77,;31.35,-6.28,;29.88,-6.75,;28.74,-5.71,;29.07,-4.21,;25.3,-.67,;23.97,.1,)|

Structure