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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glycogen synthase kinase-3 alpha | ||
| Ligand | BDBM50377239 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_479409 (CHEMBL928211) | ||
| IC50 | 172±n/a nM | ||
| Citation |  Lum, C; Kahl, J; Kessler, L; Kucharski, J; Lundström, J; Miller, S; Nakanishi, H; Pei, Y; Pryor, K; Roberts, E; Sebo, L; Sullivan, R; Urban, J; Wang, Z 2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg Med Chem Lett18:3578-81 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glycogen synthase kinase-3 alpha | |||
| Name: | Glycogen synthase kinase-3 alpha | ||
| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50991.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P49840 | ||
| Residue: | 483 | ||
| Sequence: |
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| BDBM50377239 | |||
| n/a | |||
| Name | BDBM50377239 | ||
| Synonyms: | CHEMBL256517 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H19N5O3 | ||
| Mol. Mass. | 329.3538 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)Nc1ncc(c(Nc2ccccc2)n1)[N+]([O-])=O |wU:4.7,wD:1.0,(10.05,-30.85,;10.05,-29.31,;11.38,-28.53,;11.38,-26.99,;10.05,-26.23,;8.71,-27,;8.71,-28.54,;10.05,-24.69,;8.71,-23.92,;8.7,-22.37,;7.36,-21.61,;6.04,-22.38,;6.04,-23.92,;4.7,-24.69,;4.7,-26.23,;3.36,-26.99,;3.36,-28.53,;4.69,-29.31,;6.03,-28.53,;6.03,-26.99,;7.37,-24.69,;4.7,-21.61,;4.7,-20.07,;3.37,-22.38,)| | ||
| Structure | 
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