Reaction Details |
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Target | Cholinesterase |
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Ligand | BDBM8987 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_552873 (CHEMBL960590) |
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IC50 | 196±n/a nM |
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Citation | Camps, P; Formosa, X; Galdeano, C; Gómez, T; Muñoz-Torrero, D; Scarpellini, M; Viayna, E; Badia, A; Clos, MV; Camins, A; Pallàs, M; Bartolini, M; Mancini, F; Andrisano, V; Estelrich, J; Lizondo, M; Bidon-Chanal, A; Luque, FJ Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. J Med Chem51:3588-98 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholinesterase |
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Name: | Cholinesterase |
Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
Type: | Homotetramer |
Mol. Mass.: | 68422.27 |
Organism: | Homo sapiens (Human) |
Description: | P06276 |
Residue: | 602 |
Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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BDBM8987 |
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n/a |
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Name | BDBM8987 |
Synonyms: | 6-chloro-1,2,3,4-tetrahydroacridin-9-amine | 6-chlorotacrine | 6-chlorotacrine.HCl | CHEMBL486698 | Tacrine Analogue 4 |
Type | Small organic molecule |
Emp. Form. | C13H13ClN2 |
Mol. Mass. | 232.709 |
SMILES | Nc1c2CCCCc2nc2cc(Cl)ccc12 |
Structure |
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