| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
|---|
| Ligand | BDBM50264310 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_535120 (CHEMBL983683) |
|---|
| IC50 | 440±n/a nM |
|---|
| Citation |  Kern, JC; Terefenko, EA; Fensome, A; Unwalla, R; Wrobel, J; Cohen, J; Zhu, Y; Berrodin, TJ; Yudt, MR; Winneker, RC; Zhang, Z; Zhang, P 1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators. Bioorg Med Chem Lett18:5015-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mineralocorticoid receptor |
|---|
| Name: | Mineralocorticoid receptor |
|---|
| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 107076.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08235 |
|---|
| Residue: | 984 |
|---|
| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
|
|
|
|---|
| BDBM50264310 |
|---|
| n/a |
|---|
| Name | BDBM50264310 |
|---|
| Synonyms: | 1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-7-yl)-1H-pyrrole-2-carbonitrile | CHEMBL522432 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17N3O2S |
|---|
| Mol. Mass. | 363.433 |
|---|
| SMILES | Cn1c(ccc1-c1ccc2NC(=O)COC(C)(c3ccsc3)c2c1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
