| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM10583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_811247 (CHEMBL2015199) |
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| IC50 | 25±n/a nM |
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| Citation |  Galdeano, C; Viayna, E; Sola, I; Formosa, X; Camps, P; Badia, A; Clos, MV; Relat, J; Ratia, M; Bartolini, M; Mancini, F; Andrisano, V; Salmona, M; Minguillón, C; González-Muñoz, GC; Rodríguez-Franco, MI; Bidon-Chanal, A; Luque, FJ; Muñoz-Torrero, D Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases. J Med Chem55:661-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM10583 |
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| n/a |
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| Name | BDBM10583 |
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| Synonyms: | 3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl}amino}-7,11-methanocycloocta[b]quinoline dihydrochloride | 7-chloro-15-methyl-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]-10-azatetracyclo[11.3.1.0^{2,11}.0^{4,9}]heptadeca-2(11),3,5,7,9,14-hexaen-3-amine dihydrochloride | CHEMBL2011483 | Huprine-Tacrine Heterodimer 17a |
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| Type | Small organic molecule |
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| Emp. Form. | C36H41ClN4 |
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| Mol. Mass. | 565.191 |
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| SMILES | CC1=CC2CC(C1)c1c(C2)nc2cc(Cl)ccc2c1NCCCCCCNc1c2CCCCc2nc2ccccc12 |t:1| |
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| Structure | 
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