| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 3 |
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| Ligand | BDBM50379720 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_812331 (CHEMBL2014010) |
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| IC50 | 1360±n/a nM |
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| Citation |  Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Paré, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ Discovery of P2X3 selective antagonists for the treatment of chronic pain. Bioorg Med Chem Lett22:2565-71 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 3 |
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| Name: | P2X purinoceptor 3 |
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| Synonyms: | ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa |
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| Type: | Protein |
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| Mol. Mass.: | 44292.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56373 |
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| Residue: | 397 |
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| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
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| BDBM50379720 |
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| n/a |
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| Name | BDBM50379720 |
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| Synonyms: | CHEMBL2010928 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29N5O2 |
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| Mol. Mass. | 443.5408 |
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| SMILES | CC(C)N1Cc2c(nc(nc2NC(c2ccccc2)c2ccccc2)N2CCOCC2)C1=O |
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| Structure | 
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