Reaction Details | |||
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Target | Bcl-2-like protein 1 | ||
Ligand | BDBM50384311 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_818166 (CHEMBL2033943) | ||
IC50 | 30±n/a nM | ||
Citation | Schroeder, GM; Wei, D; Banfi, P; Cai, ZW; Lippy, J; Menichincheri, M; Modugno, M; Naglich, J; Penhallow, B; Perez, HL; Sack, J; Schmidt, RJ; Tebben, A; Yan, C; Zhang, L; Galvani, A; Lombardo, LJ; Borzilleri, RM Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg Med Chem Lett22:3951-6 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bcl-2-like protein 1 | |||
Name: | Bcl-2-like protein 1 | ||
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) | ||
Type: | Mitochondrion membrane; Single-pass membrane protein | ||
Mol. Mass.: | 26039.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 233 | ||
Sequence: |
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BDBM50384311 | |||
n/a | |||
Name | BDBM50384311 | ||
Synonyms: | CHEMBL2030846 | ||
Type | Small organic molecule | ||
Emp. Form. | C41H36N4O6S | ||
Mol. Mass. | 712.813 | ||
SMILES | CCCCc1c(c(nn1-c1ccccc1)C(O)=O)-c1ccc(cc1C(=O)N1CCc2ccccc2C1)C(=O)NS(=O)(=O)c1ccc2ccccc2c1 |(47.07,-6.48,;45.76,-5.67,;45.8,-4.14,;44.49,-3.33,;44.54,-1.78,;44.7,-.25,;43.29,.38,;42.26,-.76,;43.03,-2.1,;42.31,-3.45,;40.77,-3.5,;40.04,-4.86,;40.85,-6.17,;42.4,-6.11,;43.12,-4.76,;42.98,1.89,;41.51,2.36,;44.12,2.92,;46.04,.52,;46.04,2.06,;47.38,2.83,;48.71,2.06,;48.71,.51,;47.36,-.25,;47.36,-1.79,;46.02,-2.55,;48.69,-2.57,;48.69,-4.1,;50.01,-4.88,;51.34,-4.12,;52.66,-4.9,;54.01,-4.14,;54.02,-2.6,;52.69,-1.82,;51.36,-2.58,;50.03,-1.79,;50.05,2.82,;50.06,4.36,;51.38,2.04,;52.71,2.81,;51.93,4.14,;53.47,4.15,;54.05,2.03,;54.04,.49,;55.37,-.29,;56.72,.49,;58.06,-.27,;59.4,.51,;59.38,2.06,;58.03,2.82,;56.71,2.03,;55.38,2.8,)| | ||
Structure |