| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM50385078 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_821480 (CHEMBL2038010) |
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| IC50 | 5±n/a nM |
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| Citation |  Tsuhako, AL; Brown, DS; Koltun, ES; Aay, N; Arcalas, A; Chan, V; Du, H; Engst, S; Franzini, M; Galan, A; Huang, P; Johnston, S; Kane, B; Kim, MH; Laird, AD; Lin, R; Mock, L; Ngan, I; Pack, M; Stott, G; Stout, TJ; Yu, P; Zaharia, C; Zhang, W; Zhou, P; Nuss, JM; Kearney, PC; Xu, W The design, synthesis, and biological evaluation of PIM kinase inhibitors. Bioorg Med Chem Lett22:3732-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM50385078 |
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| n/a |
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| Name | BDBM50385078 |
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| Synonyms: | CHEMBL2035629 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22BrClN4O3 |
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| Mol. Mass. | 529.813 |
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| SMILES | Clc1cc(NC(=O)CCN2CCCCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1 |
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| Structure | 
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