| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Ligand | BDBM50386475 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_827186 (CHEMBL2050520) |
|---|
| IC50 | 73±n/a nM |
|---|
| Citation |  Mathieu, S; Gradl, SN; Ren, L; Wen, Z; Aliagas, I; Gunzner-Toste, J; Lee, W; Pulk, R; Zhao, G; Alicke, B; Boggs, JW; Buckmelter, AJ; Choo, EF; Dinkel, V; Gloor, SL; Gould, SE; Hansen, JD; Hastings, G; Hatzivassiliou, G; Laird, ER; Moreno, D; Ran, Y; Voegtli, WC; Wenglowsky, S; Grina, J; Rudolph, J Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties. J Med Chem55:2869-81 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Name: | RAF proto-oncogene serine/threonine-protein kinase |
|---|
| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 73082.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04049 |
|---|
| Residue: | 648 |
|---|
| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
|---|
| BDBM50386475 |
|---|
| n/a |
|---|
| Name | BDBM50386475 |
|---|
| Synonyms: | CHEMBL2047879 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H14ClF2N5O3S2 |
|---|
| Mol. Mass. | 461.894 |
|---|
| SMILES | Nc1ncnc2c(csc12)C(=O)Nc1c(Cl)ccc(NS(=O)(=O)CCCF)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
