| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
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| Ligand | BDBM50386776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_826735 (CHEMBL2051182) |
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| IC50 | 160±n/a nM |
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| Citation |  Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem55:3837-51 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 4E |
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| Name: | Eukaryotic translation initiation factor 4E |
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| Synonyms: | EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 25095.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06730 |
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| Residue: | 217 |
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| Sequence: | MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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| BDBM50386776 |
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| n/a |
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| Name | BDBM50386776 |
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| Synonyms: | CHEMBL2046917 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN5O5P |
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| Mol. Mass. | 489.849 |
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| SMILES | CNc1nc2nc(-c3ccc(CP(O)(O)=O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 |
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| Structure | 
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