Reaction Details |
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Target | Eukaryotic translation initiation factor 4E |
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Ligand | BDBM50316304 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_826737 (CHEMBL2051184) |
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IC50 | 39000±n/a nM |
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Citation | Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem55:3837-51 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic translation initiation factor 4E |
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Name: | Eukaryotic translation initiation factor 4E |
Synonyms: | EIF4E | IF4E_RABIT |
Type: | PROTEIN |
Mol. Mass.: | 25047.40 |
Organism: | Oryctolagus cuniculus |
Description: | ChEMBL_1511842 |
Residue: | 217 |
Sequence: | MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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BDBM50316304 |
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n/a |
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Name | BDBM50316304 |
Synonyms: | ((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate | CHEMBL1097198 |
Type | Small organic molecule |
Emp. Form. | C11H16N5O8P |
Mol. Mass. | 377.2472 |
SMILES | C[n+]1cn([C@@H]2O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r| |
Structure |
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