Reaction Details |
| Report a problem with these data |
Target | Hydroxycarboxylic acid receptor 2 |
---|
Ligand | BDBM50273099 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_829215 (CHEMBL2060037) |
---|
EC50 | 286±n/a nM |
---|
Citation | Boatman, PD; Lauring, B; Schrader, TO; Kasem, M; Johnson, BR; Skinner, P; Jung, JK; Xu, J; Cherrier, MC; Webb, PJ; Semple, G; Sage, CR; Knudsen, J; Chen, R; Luo, WL; Caro, L; Cote, J; Lai, E; Wagner, J; Taggart, AK; Carballo-Jane, E; Hammond, M; Colletti, SL; Tata, JR; Connolly, DT; Waters, MG; Richman, JG (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J Med Chem55:3644-66 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Hydroxycarboxylic acid receptor 2 |
---|
Name: | Hydroxycarboxylic acid receptor 2 |
Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41868.22 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
Residue: | 363 |
Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
|
|
|
BDBM50273099 |
---|
n/a |
---|
Name | BDBM50273099 |
Synonyms: | 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole | 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole | CHEMBL456145 | MK-0354 |
Type | Small organic molecule |
Emp. Form. | C7H8N6 |
Mol. Mass. | 176.1786 |
SMILES | C1Cc2[nH]nc(c2C1)-c1nnn[nH]1 |
Structure |
|