| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50388912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_831065 (CHEMBL2065766) |
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| Ki | 205000±n/a nM |
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| Citation |  Lee, M; Ikejiri, M; Klimpel, D; Toth, M; Espahbodi, M; Hesek, D; Forbes, C; Kumarasiri, M; Noll, BC; Chang, M; Mobashery, S Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors. ACS Med Chem Lett3:490-495 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50388912 |
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| n/a |
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| Name | BDBM50388912 |
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| Synonyms: | CHEMBL2063273 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16O4S2 |
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| Mol. Mass. | 336.426 |
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| SMILES | OCc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1 |
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| Structure | 
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