| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase MARK1 |
|---|
| Ligand | BDBM50389121 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_833197 (CHEMBL2067488) |
|---|
| IC50 | 115±n/a nM |
|---|
| Citation |  Guo, C; McAlpine, I; Zhang, J; Knighton, DD; Kephart, S; Johnson, MC; Li, H; Bouzida, D; Yang, A; Dong, L; Marakovits, J; Tikhe, J; Richardson, P; Guo, LC; Kania, R; Edwards, MP; Kraynov, E; Christensen, J; Piraino, J; Lee, J; Dagostino, E; Del-Carmen, C; Deng, YL; Smeal, T; Murray, BW Discovery of pyrroloaminopyrazoles as novel PAK inhibitors. J Med Chem55:4728-39 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase MARK1 |
|---|
| Name: | Serine/threonine-protein kinase MARK1 |
|---|
| Synonyms: | KIAA1477 | MARK | MARK1 | MARK1_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 89034.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9P0L2 |
|---|
| Residue: | 795 |
|---|
| Sequence: | MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY
RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV
KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH
RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV
WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG
SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE
VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR
RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP
ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV
ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD
RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF
VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE
IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI
AFKNIASKIANELKL
|
|
|
|---|
| BDBM50389121 |
|---|
| n/a |
|---|
| Name | BDBM50389121 |
|---|
| Synonyms: | CHEMBL2064628 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H33N5O3 |
|---|
| Mol. Mass. | 427.5398 |
|---|
| SMILES | CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C(C)(C)C)[nH]nc2C1(C)C)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
