Found 3678 hits with Last Name = 'christensen' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601067
(CHEMBL5208088 | US11702418, Example 6-4)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601075
(CHEMBL5202472 | US11702418, Example 6-9)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601069
(CHEMBL5191446 | US11702418, Example 6-7)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(C)C(=O)C1)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601065
(CHEMBL5206295 | US11702418, Example 4-4)Show SMILES CNCc1ccccc1-c1csc(c1)[C@@H](C)Nc1nnc(C)c2cc(OC)c(OC)cc12 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601076
(CHEMBL5209371 | US11702418, Example 6-12)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat)) | BDBM50275302
((R)-3-((3-Methylazetidine-1-carbonyloxy)-1-methylp...)Show InChI InChI=1S/C11H22N2O2/c1-9-7-13(8-9)11(14)15-6-5-10(2)12(3)4/h9-10H,5-8H2,1-4H3/t10-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells |
J Med Chem 51: 7380-95 (2009)
Article DOI: 10.1021/jm701625v
BindingDB Entry DOI: 10.7270/Q2DF6S4D |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396942
(CHEMBL2170818)Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cn[nH]c1 Show InChI InChI=1S/C17H12N8/c1-2-12-6-11(3-4-14(12)18-5-1)10-25-17-16(23-24-25)19-9-15(22-17)13-7-20-21-8-13/h1-9H,10H2,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601072
(CHEMBL5176365 | US11702418, Example 9-2)Show SMILES C[C@@H](Nc1nnc(N(C)C)c2ccc(cc12)N1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396976
(CHEMBL2170969)Show SMILES C[C@H](C(=O)NN=C1C(=O)Nc2c1c(Cl)ccc2C)c1ccc(O)cc1 |r,w:5.4| Show InChI InChI=1S/C18H16ClN3O3/c1-9-3-8-13(19)14-15(9)20-18(25)16(14)21-22-17(24)10(2)11-4-6-12(23)7-5-11/h3-8,10,23H,1-2H3,(H,22,24)(H,20,21,25)/t10-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440904
(CHEMBL2431834)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C19H16N8/c1-12(13-5-6-16-14(8-13)4-3-7-20-16)27-19-18(24-25-27)21-10-17(23-19)15-9-22-26(2)11-15/h3-12H,1-2H3/t12-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601083
(CHEMBL5193021)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(Br)c1C |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601084
(CHEMBL5192659 | US11702418, Example 12-10)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(C#N)c1C |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay |
J Med Chem 54: 6342-63 (2011)
Article DOI: 10.1021/jm2007613
BindingDB Entry DOI: 10.7270/Q2Q52Q09 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396954
(CHEMBL2170966)Show SMILES CNc1snc(SCc2nnc3ncc(nn23)-c2ccc(F)cc2)c1C(N)=O Show InChI InChI=1S/C16H13FN8OS2/c1-19-14-12(13(18)26)15(24-28-14)27-7-11-21-22-16-20-6-10(23-25(11)16)8-2-4-9(17)5-3-8/h2-6,19H,7H2,1H3,(H2,18,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat)) | BDBM50275302
((R)-3-((3-Methylazetidine-1-carbonyloxy)-1-methylp...)Show InChI InChI=1S/C11H22N2O2/c1-9-7-13(8-9)11(14)15-6-5-10(2)12(3)4/h9-10H,5-8H2,1-4H3/t10-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells |
J Med Chem 51: 7380-95 (2009)
Article DOI: 10.1021/jm701625v
BindingDB Entry DOI: 10.7270/Q2DF6S4D |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601066
(CHEMBL5179610 | US11702418, Example 10-45)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N(C)C)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601085
(CHEMBL5198950 | US11702418, Example 6-19)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(c1C)S(C)(=O)=O |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 1
(RAT) | BDBM50060627
((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...)Show InChI InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Curated by ChEMBL
| Assay Description
Displacement of [3H]SYM2081 from rat recombinant iGluR5(Q)1b expressed in Sf9 cells |
J Med Chem 51: 6614-8 (2008)
Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601091
(CHEMBL5171096 | US11702418, Example 4-1)Show SMILES COc1cc2c(C)nnc(N[C@H](C)c3cccc(c3C)C(F)(F)F)c2cc1OC |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PAK 4
(Homo sapiens (Human)) | BDBM50389112
(CHEMBL2064556)Show SMILES CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccc(NCc5ccc(cc5)-c5ccccn5)cc4[nH]3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C37H34N8O/c1-45(2)23-34(25-8-4-3-5-9-25)42-37(46)27-15-17-31-29(20-27)35(44-43-31)36-40-32-18-16-28(21-33(32)41-36)39-22-24-11-13-26(14-12-24)30-10-6-7-19-38-30/h3-21,34,39H,22-23H2,1-2H3,(H,40,41)(H,42,46)(H,43,44)/t34-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PAK4 |
J Med Chem 55: 4728-39 (2012)
Article DOI: 10.1021/jm300204j
BindingDB Entry DOI: 10.7270/Q2BZ673W |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440905
(CHEMBL2431835)Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1 |r| Show InChI InChI=1S/C20H18N8O/c1-13(14-4-5-17-15(9-14)3-2-6-21-17)28-20-19(25-26-28)22-11-18(24-20)16-10-23-27(12-16)7-8-29/h2-6,9-13,29H,7-8H2,1H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Glutamate receptor 1
(Rattus norvegicus (Rat)) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Curated by ChEMBL
| Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR1 expressed in Sf9 cells |
J Med Chem 51: 6614-8 (2008)
Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440879
(CHEMBL2431824)Show SMILES COc1ccc(cc1C)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1 |r| Show InChI InChI=1S/C24H21N5O/c1-15-13-19(7-10-22(15)30-3)21-9-11-23-26-27-24(29(23)28-21)16(2)17-6-8-20-18(14-17)5-4-12-25-20/h4-14,16H,1-3H3/t16-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601077
(CHEMBL5176509 | US11702418, Example 12-50)Show SMILES C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCOCC1)c1cccc(c1F)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601068
(CHEMBL5176696)Show SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)C1CCNCC1)c1cccc(c1C)C(F)(F)F |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50389111
(CHEMBL2064555)Show SMILES CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C25H24N6O/c1-31(2)15-22(16-8-4-3-5-9-16)28-25(32)17-12-13-19-18(14-17)23(30-29-19)24-26-20-10-6-7-11-21(20)27-24/h3-14,22H,15H2,1-2H3,(H,26,27)(H,28,32)(H,29,30)/t22-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
J Med Chem 55: 4728-39 (2012)
Article DOI: 10.1021/jm300204j
BindingDB Entry DOI: 10.7270/Q2BZ673W |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat)) | BDBM50274819
(3-((Cyclopropanecarbonyloxy)-1-methylpropyl)dimeth...)Show InChI InChI=1S/C10H19NO2/c1-8(11(2)3)6-7-13-10(12)9-4-5-9/h8-9H,4-7H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells |
J Med Chem 51: 7380-95 (2009)
Article DOI: 10.1021/jm701625v
BindingDB Entry DOI: 10.7270/Q2DF6S4D |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1
(Homo sapiens (Human)) | BDBM50601064
(CHEMBL5174300 | US11702418, Example 1-14)Show SMILES CNCc1ccccc1-c1csc(c1)[C@@H](C)Nc1nncc2cc(OC)c(OC)cc12 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00741
BindingDB Entry DOI: 10.7270/Q2XD15Q0 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440896
(CHEMBL2431826)Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cccc(c1)C#N)c1ccc2ncccc2c1 |r| Show InChI InChI=1S/C23H16N6/c1-15(17-7-8-20-19(13-17)6-3-11-25-20)23-27-26-22-10-9-21(28-29(22)23)18-5-2-4-16(12-18)14-24/h2-13,15H,1H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440899
(CHEMBL2431829)Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc2OCCOc2c1)c1ccc2ncccc2c1 |r| Show InChI InChI=1S/C24H19N5O2/c1-15(16-4-6-19-17(13-16)3-2-10-25-19)24-27-26-23-9-7-20(28-29(23)24)18-5-8-21-22(14-18)31-12-11-30-21/h2-10,13-15H,11-12H2,1H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440893
(CHEMBL2431822)Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(F)c(F)c1)c1ccc2ncccc2c1 |r| Show InChI InChI=1S/C22H15F2N5/c1-13(14-5-7-19-15(11-14)3-2-10-25-19)22-27-26-21-9-8-20(28-29(21)22)16-4-6-17(23)18(24)12-16/h2-13H,1H3/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396952
(CHEMBL2170968)Show SMILES N#Cc1ccc(cc1)-c1cnc2nnc(Cc3c[nH]c4ncccc34)n2n1 Show InChI InChI=1S/C19H12N8/c20-9-12-3-5-13(6-4-12)16-11-23-19-25-24-17(27(19)26-16)8-14-10-22-18-15(14)2-1-7-21-18/h1-7,10-11H,8H2,(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396970
(CHEMBL2170954)Show InChI InChI=1S/C16H15N7/c1-2-17-14-9-19-15-16(20-14)23(22-21-15)10-11-5-6-13-12(8-11)4-3-7-18-13/h3-9H,2,10H2,1H3,(H,17,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Glutamate receptor 2
(Rattus norvegicus) | BDBM50060635
((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)Show InChI InChI=1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs)
Curated by ChEMBL
| Assay Description
Displacement of (R,S)-[5-methyl-3H]AMPA from rat recombinant flop iGluR2(R) expressed in Sf9 cells |
J Med Chem 51: 6614-8 (2008)
Article DOI: 10.1021/jm800865a
BindingDB Entry DOI: 10.7270/Q261117R |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440894
(CHEMBL2431823)Show SMILES COc1ccc(cc1F)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1 |r| Show InChI InChI=1S/C23H18FN5O/c1-14(15-5-7-19-16(12-15)4-3-11-25-19)23-27-26-22-10-8-20(28-29(22)23)17-6-9-21(30-2)18(24)13-17/h3-14H,1-2H3/t14-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396947
(CHEMBL2169896)Show InChI InChI=1S/C20H13FN6/c21-16-6-4-14(5-7-16)18-11-23-19-20(24-18)27(26-25-19)12-13-3-8-17-15(10-13)2-1-9-22-17/h1-11H,12H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440895
(CHEMBL2431825)Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cccc(C)c1)c1ccc2ncccc2c1 |r| Show InChI InChI=1S/C23H19N5/c1-15-5-3-6-18(13-15)21-10-11-22-25-26-23(28(22)27-21)16(2)17-8-9-20-19(14-17)7-4-12-24-20/h3-14,16H,1-2H3/t16-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396934
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-4
(Rattus norvegicus (Rat)) | BDBM50275265
(3-((Azetidine-1-carbonyloxy)-1-methylpropyl)dimeth...)Show InChI InChI=1S/C10H20N2O2/c1-9(11(2)3)5-8-14-10(13)12-6-4-7-12/h9H,4-8H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells |
J Med Chem 51: 7380-95 (2009)
Article DOI: 10.1021/jm701625v
BindingDB Entry DOI: 10.7270/Q2DF6S4D |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Rattus norvegicus (Rat)) | BDBM50275304
(3-((2-Methylazetidine-1-carbonyloxy)-1-methylpropy...)Show InChI InChI=1S/C11H22N2O2/c1-9(12(3)4)6-8-15-11(14)13-7-5-10(13)2/h9-10H,5-8H2,1-4H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen
Curated by ChEMBL
| Assay Description
Agonist activity at rat alpha-3-beta-4 nAChR expressed in HEK293 cells by FMP assay |
J Med Chem 51: 7380-95 (2009)
Article DOI: 10.1021/jm701625v
BindingDB Entry DOI: 10.7270/Q2DF6S4D |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440898
(CHEMBL2431828)Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccccc1C#N)c1ccc2ncccc2c1 |r| Show InChI InChI=1S/C23H16N6/c1-15(16-8-9-20-17(13-16)6-4-12-25-20)23-27-26-22-11-10-21(28-29(22)23)19-7-3-2-5-18(19)14-24/h2-13,15H,1H3/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396943
(CHEMBL2170816)Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396943
(CHEMBL2170816)Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396953
(CHEMBL2170967)Show InChI InChI=1S/C20H13FN6/c21-16-6-4-14(5-7-16)18-12-23-20-25-24-19(27(20)26-18)11-13-3-8-17-15(10-13)2-1-9-22-17/h1-10,12H,11H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase PAK 4
(Homo sapiens (Human)) | BDBM50389111
(CHEMBL2064555)Show SMILES CN(C)C[C@@H](NC(=O)c1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)c1ccccc1 |r| Show InChI InChI=1S/C25H24N6O/c1-31(2)15-22(16-8-4-3-5-9-16)28-25(32)17-12-13-19-18(14-17)23(30-29-19)24-26-20-10-6-7-11-21(20)27-24/h3-14,22H,15H2,1-2H3,(H,26,27)(H,28,32)(H,29,30)/t22-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PAK4 |
J Med Chem 55: 4728-39 (2012)
Article DOI: 10.1021/jm300204j
BindingDB Entry DOI: 10.7270/Q2BZ673W |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396941
(CHEMBL2170819)Show SMILES OC(=O)Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 Show InChI InChI=1S/C19H14N8O2/c28-17(29)11-26-10-14(7-22-26)16-8-21-18-19(23-16)27(25-24-18)9-12-3-4-15-13(6-12)2-1-5-20-15/h1-8,10H,9,11H2,(H,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396936
(CHEMBL2170949)Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(c1)[C@@H]1CCNC1 |r| Show InChI InChI=1S/C21H19N9/c1-2-15-8-14(3-4-18(15)23-6-1)12-30-21-20(27-28-30)24-11-19(26-21)16-9-25-29(13-16)17-5-7-22-10-17/h1-4,6,8-9,11,13,17,22H,5,7,10,12H2/t17-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440900
(CHEMBL2431830)Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1 |r| Show InChI InChI=1S/C24H20N6O/c1-15(18-9-10-20-19(14-18)4-3-13-26-20)23-28-27-22-12-11-21(29-30(22)23)16-5-7-17(8-6-16)24(31)25-2/h3-15H,1-2H3,(H,25,31)/t15-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50396967
(CHEMBL2170806)Show SMILES N[C@@H]1CCN(C1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 |r| Show InChI InChI=1S/C18H18N8/c19-14-5-7-25(11-14)16-9-21-17-18(22-16)26(24-23-17)10-12-3-4-15-13(8-12)2-1-6-20-15/h1-4,6,8-9,14H,5,7,10-11,19H2/t14-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry |
J Med Chem 55: 8091-109 (2012)
Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50440880
(CHEMBL2431836)Show SMILES CC(C)Nc1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1 |r| Show InChI InChI=1S/C19H20N6/c1-12(2)21-17-8-9-18-22-23-19(25(18)24-17)13(3)14-6-7-16-15(11-14)5-4-10-20-16/h4-13H,1-3H3,(H,21,24)/t13-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay |
J Med Chem 56: 6651-65 (2013)
Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR |
More data for this
Ligand-Target Pair | |
Search and Browse
