Reaction Details |
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Target | Ceramide glucosyltransferase |
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Ligand | BDBM50394813 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_859947 (CHEMBL2167350) |
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IC50 | 190±n/a nM |
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Citation | Richards, S; Larson, CJ; Koltun, ES; Hanel, A; Chan, V; Nachtigall, J; Harrison, A; Aay, N; Du, H; Arcalas, A; Galan, A; Zhang, J; Zhang, W; Won, KA; Tam, D; Qian, F; Wang, T; Finn, P; Ogilvie, K; Rosen, J; Aoyama, R; Plonowski, A; Cancilla, B; Bentzien, F; Yakes, M; Mohan, R; Lamb, P; Nuss, J; Kearney, P Discovery and characterization of an inhibitor of glucosylceramide synthase. J Med Chem55:4322-35 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ceramide glucosyltransferase |
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Name: | Ceramide glucosyltransferase |
Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
Type: | PROTEIN |
Mol. Mass.: | 44859.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1435474 |
Residue: | 394 |
Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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BDBM50394813 |
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n/a |
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Name | BDBM50394813 |
Synonyms: | CHEMBL2163837 |
Type | Small organic molecule |
Emp. Form. | C24H25Cl4N3O2 |
Mol. Mass. | 529.286 |
SMILES | C[C@H]1CN(CCN1)C(=O)[C@H](Cc1ccc(Cl)cc1Cl)NC(=O)C1(CC1)c1ccc(Cl)cc1Cl |r| |
Structure |
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