| Reaction Details |
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 | Report a problem with these data |
| Target | Ceramide glucosyltransferase |
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| Ligand | BDBM50299749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_859947 (CHEMBL2167350) |
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| IC50 | 90±n/a nM |
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| Citation |  Richards, S; Larson, CJ; Koltun, ES; Hanel, A; Chan, V; Nachtigall, J; Harrison, A; Aay, N; Du, H; Arcalas, A; Galan, A; Zhang, J; Zhang, W; Won, KA; Tam, D; Qian, F; Wang, T; Finn, P; Ogilvie, K; Rosen, J; Aoyama, R; Plonowski, A; Cancilla, B; Bentzien, F; Yakes, M; Mohan, R; Lamb, P; Nuss, J; Kearney, P Discovery and characterization of an inhibitor of glucosylceramide synthase. J Med Chem55:4322-35 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ceramide glucosyltransferase |
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| Name: | Ceramide glucosyltransferase |
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| Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44859.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1435474 |
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| Residue: | 394 |
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| Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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| BDBM50299749 |
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| n/a |
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| Name | BDBM50299749 |
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| Synonyms: | (2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]-2-hydroxymethyl-piperidine-3,4,5-triol | CHEMBL574645 | N-adamantanemethyloxypentyl-1-deoxynojirimycin |
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| Type | Small organic molecule |
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| Emp. Form. | C22H39NO5 |
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| Mol. Mass. | 397.5488 |
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| SMILES | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 |r,TLB:21:22:19.20.25:26,THB:21:20:26:27.22.23,23:22:19:25.24.26,23:24:19:27.21.22| |
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| Structure | 
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