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TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase
LigandBDBM50395905
Substrate/Competitorn/a
Meas. Tech.ChEMBL_858075
IC50 1.95±n/a nM
Citation McAllister LAMontgomery JIAbramite JAReilly UBrown MFChen JMBarham RAChe YChung SWMenard CAMitton-Fry MMullins LMNoe MCO'Donnell JPOliver RMPenzien JBPlummer MPrice LMShanmugasundaram VTomaras APUccello DP Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents. Bioorg Med Chem Lett 22:6832-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Name:UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:lpxC
Type:PROTEIN
Mol. Mass.:21890.40
Organism:Pseudomonas aeruginosa
Description:ChEMBL_858075
Residue:197
Sequence:
TVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKRE
VSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFM
RDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLI
GEFRGFKSGHALNNQLL
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BDBM50395905
n/a
NameBDBM50395905
Synonyms:CHEMBL2164184
TypeSmall organic molecule
Emp. Form.C14H16Cl2N4O4S
Mol. Mass.407.272
SMILESC[C@@](CCn1cc(nn1)-c1cccc(Cl)c1Cl)(C(=O)NO)S(C)(=O)=O |r|
Structure
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