| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM50397054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_863458 (CHEMBL2174655) |
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| IC50 | 63±n/a nM |
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| Citation |  Banerjee, A; Patil, S; Pawar, MY; Gullapalli, S; Gupta, PK; Gandhi, MN; Bhateja, DK; Bajpai, M; Sangana, RR; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model. Bioorg Med Chem Lett22:6286-91 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | P2A | PDE7A_MOUSE | Pde7a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52494.24 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_863458 |
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| Residue: | 456 |
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| Sequence: | MGITLIWCLALVLIKWITSKRRGAISYDSSDQTALYIRMLGDVRVRSRAGFETERRGSHP
YIDFRIFHSQSDIEASVSARNIRRLLSFQRYLRSSRVFRGATVCSSLDILDEDYNGQAKC
MLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYH
SQNPYHNAVHAADVTQAMHCYLKEPKLASSVTPWDILLSLIAAATHDLDHPGVNQPFLIK
TNHYLATLYKNSSVLENHHWRSAVGLLRESGLFSHLPLESRQEMEAQIGALILATDISRQ
NEYLSLFRSHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFH
QGDIEKKYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSDTRLSQTMLGHVGL
NKASWKGLQRQQPSSEDANAAFELNSQLLTQENRLS
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| BDBM50397054 |
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| n/a |
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| Name | BDBM50397054 |
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| Synonyms: | CHEMBL2171421 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O2 |
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| Mol. Mass. | 353.4182 |
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| SMILES | COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 |
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| Structure | 
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