Reaction Details |
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Target | Cathepsin E |
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Ligand | BDBM50427565 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_941701 (CHEMBL2330924) |
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IC50 | 11000±n/a nM |
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Citation | Lorthiois, E; Breitenstein, W; Cumin, F; Ehrhardt, C; Francotte, E; Jacoby, E; Ostermann, N; Sellner, H; Kosaka, T; Webb, RL; Rigel, DF; Hassiepen, U; Richert, P; Wagner, T; Maibaum, J The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches. J Med Chem56:2207-17 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin E |
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Name: | Cathepsin E |
Synonyms: | 3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II |
Type: | Enzyme |
Mol. Mass.: | 43298.99 |
Organism: | Homo sapiens (Human) |
Description: | P14091 |
Residue: | 396 |
Sequence: | MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
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BDBM50427565 |
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n/a |
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Name | BDBM50427565 |
Synonyms: | CHEMBL2322896 |
Type | Small organic molecule |
Emp. Form. | C24H25ClN2 |
Mol. Mass. | 376.922 |
SMILES | Clc1ccc(cc1)N(C[C@@H]1CNC[C@H]1Cc1ccccc1)c1ccccc1 |r| |
Structure |
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